Rigorous Evaluation of Primary and Secondary Overdose Prevention Activities Among Populations Disproportionately Affected by Overdose


The Centers for Disease Control and Prevention’s (CDC) National Center for Injury Prevention and Control (NCIPC, Injury Center) is soliciting investigator-initiated research to develop, implement, and rigorously evaluate prevention strategies among populations or communities experiencing disproportionate burden of drug overdose or those who are at greater risk of exposure to drug use and experiencing adverse outcomes related to drug use due to social determinants of health. Funding can be used to develop, implement, and rigorously evaluate strategies that (1) prevent adverse outcomes related to drug use among those not yet engaged in drug use (i.e., primary prevention) or (2) reduce adverse outcomes among those already engaged in drug use by linking and retaining them in care (i.e., secondary prevention). The proposed research should rigorously evaluate either primary or secondary prevention strategies, on reducing rates of at least two primary outcomes from this list: nonfatal overdose, fatal overdose, substance use disorders involving federally illicit drugs or misuse of prescription medications, drug use, or initiation of drug use particularly among youth.