The National Institute on Drug Abuse (NIDA) intends to reissue PAR-19-259 for new applications that will support investigator initiated Research Centers of Excellence that will investigate drug abuse and addiction research. Applicants must apply and undergo peer review. The Funding Opportunity Announcement (FOA) will provide support for research Centers that (1) conduct drug abuse and addiction research in any area of NIDA’s mission, (2) have outstanding innovative science, (3) are multidisciplinary, thematically integrated, synergistic, and (4) serve as national resource(s) to provide educational and outreach activities to drug abuse research communities, educational organizations, the general public, and policy makers in the NIDA research fields. It is expected that a Center will transform knowledge in the sciences it is studying. Incremental work should not be the focus of Center activities; rather, new and creative directions are required. The P50 Center of Excellence is expected to foster the career development and mentoring of new investigators who would be given meaningful roles to play in the Center projects. A goal of this program is to create NIDA Centers that are national community resources for furthering drug abuse research by sharing their findings, their data, and their resources as appropriate for researchers to use and build upon and to advance research in this field. This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. The FOA is expected to be published by Winter 2022 with an expected application due date in Fall 2022. This FOA will utilize the P50 activity code. Details of the planned FOA are provided below.